Facilitating parameter estimation and sensitivity analysis. Robustness can also be verified in some confidence intervals by simply looking at the. Mathematical models are utilized to approximate various highly complex engineering, physical, environmental, social, and economic phenomena. In this paper, we investigate whether this correlation is valid for a larger class of model functions. At the completion of an analysis on parameter sensitivity the analyst holds a list, or sensitivity ranking, of the input parameters sorted by the amount of. Parameter estimation and sensitivity analysis fathalla a. Parameter estimation for linear compartmental modelsa. Our analysis is designed to make this kind of transparency easier to deliver for nonlinear models. However, an increase in baseline coolant temperature by 30 degrees kelvin generates oscil lations that come close to instability when the coolant temperature decreases, something that is undesirable in an actual industrial process. Mar 12, 2018 a parameter sensitivity analysis based on qr factorization 22 is applied to find a subset of parameters that can be reliably estimated, which leads to a simplified estimation procedure. Parameter scanning, parameter estimation, and sensitivity. Each plot shows the plugin sensitivity of the parameter named in the plot title with respect to the full vector of estimation moments, which are the mean adjusted log of consumption levels at each age. In order that these parameter sensitivity simulations are as similar as possible to our future parameter estimation simulations, a technique is developed and implemented that constrains the model parameters to lie within the physically realistic ranges specified in table 1. Free fulltext pdf articles from hundreds of disciplines, all in one place using sensitivity equations for computing gradients of the foce and focei approximations to the population likelihood pdf paperity.
Pdf parameter estimation in stochastic differential. Stochastic differential equations turn out to be an advantageous representation of such noisy, realworld problems, and together with their identification, they play. Sensitivity analysis of aquifer parameter estimations based on the laplace equation with linearized boundary conditions jozsef szilagyi conservation and survey division, university of nebraskalincoln, lincoln, nebraska, usa. However, this approach only focuses on the parameter estimation errors. Linear compartmental models are useful, explanatory tools, that have been widely used to represent the dynamic behavior of complex biological systems. The transitional probability density function pdf, which is an integral component in the construction of the likelihood function, is wellknown to satisfy a partial di. Facilitating parameter estimation and sensitivity analysis of. A comparison of three adsorption equations and sensitivity study of parameter uncertainty effects on adsorption refrigeration thermal performance estimation. Sensitivity analysis of aquifer parameter estimations. Siam journal on scientific computing society for industrial. A new method for parameter sensitivity analysis of lorenz. Albany, new york 12208 national oceanic and,4 lttoyheric, administration, great lakes enviroti. Pdf maximum likelihood parameter estimation from incomplete.
For example, a model has five parameters and it is deter mined, rather. Parameter scanning, parameter estimation, and sensitivity analysis in the yeast heterotrimeric g protein cycle open script this example shows how to build, simulate and analyze a model in simbiology using a pathway taken from the literature. Cao mcgill university, montreal, canada read before the royal statistical society at a meeting organized by the research section on wednesday, may 9th, 2007, professor t. Rihan department of mathematical sciences, college of science, uae university, al ain, 15551, uae email. The transitional probability density function pdf, which is an integral com. Estimation of the parameters of stochastic differential equations. A related practice is uncertainty analysis, which has a greater focus on uncertainty quantification and propagation of uncertainty. Yet, sensitivity equations for models with parameter and statedependent events and eventtriggered observations are not supported by existing toolboxes. Parameter estimation, sensitivity analysis and optimal control of a periodic epidemic model with application to hrsv in florida silve.
In particular, in this paper we investigate the problem of. The applicability of sensitivity functions to parameter estimation of nonlinear, time variant systems was investigated. The first step towards this end has in fact already been taken through the successful application of sensitivity equations for computing. A sensitive parameter, however, is not necessarily important because it may be known precisely, thereby having little variability to add to the output. Model parameters exerting the most influence on model results are identified through a sensitivity analysis. Our overall aim is to make agentbased modellers aware of existing methods and tools for parameter estimation and sensitivity analysis and to. A generalized smoothing approach 5 a concern in dynamic systems modeling is the possibly complex nature of the.
The method showed the ability to move the parameter vector toward the direction of optimality, but the nonlinearity of the system created problems of. Sensitivity of response functions in variational data. Estimation of road load parameters via onroad vehicle. Financial processes as processes in nature, are subject to stochastic fluctuations.
If the parameters of a model are unknown, results from simu. Ideally a dde modeling package should provide facilities for approximating the solution, performing a sensitivity analysis and estimating unknown parameters. Using matlab to perform nonlinear parameter estimation the two main functions for parameter estimation are nlinfit, lsqnonlin, and cftool graphic user interface. Jul 25, 2006 we study model nonlinearity and sensitivity for parameter estimation problems.
Choice of the nonlinear parameter estimation method if nothing is known about the errors none of the 8 assumptions are known, use ordinary least squares ols. The sensitivity equations are derived based on the staggered methods. Sensitivity and specificity values alone may be highly misleading. A parameter sensitivity analysis based on qr factorization 22 is applied to find a subset of parameters that can be reliably estimated, which leads to a simplified estimation procedure. Experimental results indicate that it is possible to determine effects of parameters on model variables so that we can eliminate the less effective ones. Approaches developed for parsimonious hydrological models. Sensitivity analysis is the study of how the uncertainty in the output of a mathematical model or system numerical or otherwise can be divided and allocated to different sources of uncertainty in its inputs. For models without events, gradient based optimization schemes perform well for parameter estimation, when sensitivity equations are used for gradient computation. Jan 27, 2017 we consider a system of nonlinear delay differential equations that. Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting m. The sensitivity analysis and parameter estimation of mathematical. Our overall aim is to make agentbased modellers aware of existing methods and tools for parameter estimation and sensitivity analysis and to provide accessible tools for using these methods. The corresponding probability density function pdf.
Pdf optimization and sensitivity analysis for multiresponse. Additionally, an experimental input current profile is designed for estimation and all data are collected from 12 ah nickel cobalt aluminum nca li. First order conditional estimation foce, sensitivity equations. Nonlinearity, scale, and sensitivity for parameter. Parameter sensitivity analysis is thus used to decide how sensitive the results of propagation of a parameter by varying the estimation of the parameter in a model.
Parameter estimation for rough differential equations 3 scale, that is, in some limit its dynamics follow a di. This paper addresses the problem of the numerical identification of such models, i. Methodology for the simultaneous solution of ordinary differential equations odes and associated parametric sensitivity equations using the decoupled direct method ddm is presented with respect to its applicability to multiresponse parameter estimation for systems described by nonlinear ordinary differential equations. Parameter estimation and sensitivity analysis of an optimal. Using sensitivity equations for computing gradients of the foce. Parameter estimation and sensitivity analysis for a mathematical model with time delays of. An adjoint sensitivity method is presented for parameter dependent differentialalgebraic equation systems daes. The sensitivity analysis and parameter estimation of. The basic idea of equationfree modelling is to run the code for a short time and use the output to locally estimate the parameters of. Parameter estimation and uncertainty quantification for systems biology models. Bayesian parameter estimation for nonlinear dynamics using. Estimation of the parameters of stochastic differential. The results obtained in this fashion are then utilized to estimate parameter sensitivity.
A bayesian approach for global sensitivity analysis of multifidelity. The adjoint system is derived, along with conditions for its consistent initializa. However, in distributed hydrological models, parameters are discretized according to the spatial discretization of the model state variables. Parameter estimation in ordinary differential equations. Using sensitivity equations for computing gradients of the. The basic idea of equationfree modelling is to run the code for a short time and use the output to locally estimate the parameters of the di. The sensitivity analysis of mathematical models described. Parameter estimation for dynamical systems with discrete events. We study model nonlinearity and sensitivity for parameter estimation problems. To open the sensitivity analysis tool, in the parameter estimation tab, click sensitivity analysis. Parameter estimation and sensitivity analysis of an optimal control. Efficient simulation, accurate sensitivity analysis and. Maximum likelihood parameter estimation 1 1 let x0. A numeric method for analyzing global parameter sensitivity about a fixed point in parameter space for differential equation models is presented.
A method for parameter sensitivity analysis in differential. The sensitivity analysis of mathematical models described by differential equations. Parameter estimation for dynamical systems with discrete. Parameter estimation, sensitivity analysis and optimal control of a periodic epidemic model with application to hrsv in florida. Pdf sensitivity analysis of parameters in modelling with delay. Parameter estimation of nonlinear, timevariant systems by.
Sensitivity of ultrasonic wave velocity estimation using the. The supplementary material includes full, adaptable code samples for using the presented methods with r and netlogo. Luis espinosa, a,b, loic brancheriau, a flavio prieto, b and philippe lasaygues c. Our approach considers odes with unknown parameters over which a prior distribution is defined. A new method for parameter sensitivity analysis of lorenz equations is presented. When parameter estimation and sensitivity analysis are carried out in the statistical framework, it is necessary to sample the space of uncertain inputs. Parameter estimation for differential equations cornell university. Evaluation of planetary boundary layer scheme sensitivities. If covariance of errors is known, use maximum likelihood ml if covariance of errors and covariance of parameter are known, use maximum a posteriori map. Measuring the sensitivity of parameter estimates to. Maximum likelihood parameter estimation from incomplete data via the sensitivity equations. Practical identifiability analysis of large environmental.
A method for parameter sensitivity analysis in differential equation models division of computer science, albany medical college. I prefer nlinfit because the statistics on the parameter and the predicted value are obtained more. A sensitivity equation is generated from a model equation by taking the partial derivative on both sides of the model equation with respect to a fitting parameter. Estimation of the parameters of stochastic differential equations by joseph jeisman a thesis submitted to the.
Estimate parameters from measured data about this tutorial. Sensitivity of ultrasonic wave velocity estimation using. Mathematical models described by differential equations. The sensitivity analysis of mathematical models described by differential equations hossein zivaripiran. Slide 1 estimation of road load parameters via onroad vehicle testin g dr. Parameter estimation in ordinary differential equations for. The most fundamental of sensitivity techniques utilizes partial differentiation whereas the simplest approach requires varying parameter values oneatatime. The mathematical system for the butterfly valve is described in the following equation. The socalled sensitivity approach can be used to achieve a desired accuracy. The sensitivity analysis of mathematical models described by. We derive a measure of the sensitivity of an estimator to. Sensitivity of select parameters in gourinchas and parker 2002 to local violations of identifying assumptions. Nonlinearity, scale, and sensitivity for parameter estimation. The first step towards this end has in fact already been taken through the successful application of sensitivity equations for computing gradients in stochastic differential equation models on the singlesubject level.
Parameter estimation for rough differential equations. Sensitivity analysis and material parameter estimation using. Dynamic modeling, parameter estimation and uncertainty analysis. Parameter estimation and sensitivity analysis of an optimal control model for capital asset management. For simplicity let us take the case of single unknown parameter. Parameter estimation, sensitivity analysis and optimal. Sensitivity of ultrasonic wave velocity estimation using the christoffel equation for wood nondestructive characterization. Greens functions are used to avoid solving the differential equations for each model parameter each time the basecase parameter values are changed hall et al, 1982. A sensitivity matrix based methodology for inverse problem. A mathematical model comprises parameters, in which the more the parameters existing in the model, the higher the dimension of the model and the more complex to solve. The use of the saem algorithm in monolix software for estimation of population pharmacokineticpharmacodynamicviral dynamics parameters of maraviroc in asymptomatic hiv subjects. The method showed the ability to move the parameter vector toward the direction of optimality, but the nonlinearity of the system created problems of stability and rate of convergence of the algorithm.
Estimation of errors in quoted sensitivity or specificity. An initial value problem ivp for ordinary differential equations odes y. Parameter estimation and sensitivity analysis of an. The enkf does not know about physical constraints on model parameters. Sensitivity analysis and parameter estimation for distributed. Parameter estimation and sensitivity analysis for a. Measuring the sensitivity of parameter estimates to estimation moments isaiah andrews matthew gentzkow jesse m. Parameter estimation, sensitivity analysis and optimal control of a. Pdf a comparison of three adsorption equations and. In the deterministic framework, both sensitivity analysis and parameter estimation can be addressed using varia. Using sensitivity equations for computing gradients of the foce and focei approximations to the population likelihood. We consider a dynamic formulation of variational data assimilation problem for joint parameter and initial state estimation in a continuous form, but the presented sensitivity analysis formulas with respect to observations do not follow from our previous results and and constitute a novelty of this paper.
In silico investigations by simulating dynamical models of biochemical processes play an important role in systems biology. Parameter estimation and sensitivity analysis for a mathematical model with time delays of leukemia. In the sensitivity analysis tool, you can identify the model parameters that. An adjoint sensitivity method is presented for parameterdependent differentialalgebraic equation systems daes. We then condition this model on noisy observations over time, to compute a posterior distribution using the bayes rule. Optimization and sensitivity analysis for multiresponse. On the other hand, a method giving confidence intervals for the sobol. The worstcase sensitivity or specificity must be calculated in order to avoid reliance on experiments with few results.
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